Molecular BiologybioRxivPreprint
Histone lactylation H3K18la and acetylation H3K27ac encode two separable epigenomic features for enhancer regulation
Tetsuro Komatsu, Takeshi Inagaki
This study identifies H3K18la and H3K27ac as distinct epigenomic features that encode separate aspects of enhancer regulation, with H3K18la associated with lineage-specific factors and p300/CBP dependency, while H3K27ac is linked to BRD4/MED1 and phase separation.