Nishigandha N. Phalke

The paper introduces a data model for longitudinal multimodal biomedical cohorts, demonstrating its ability to manage heterogeneous data across multiple modalities and study visits.

The paper expands the ENCODE Registry of candidate cis-regulatory elements (cCREs) to include 2.35 million human and 927 thousand mouse cCREs, revealing novel regulatory functions and identifying KLF1 as a causal gene for red blood cell traits.

The paper processes single-nuclei multi-omics data from 388 human brains to identify regulatory elements and build cell-type networks, revealing changes in aging and neuropsychiatric disorders.

The paper updates Factorbook, a TF-centric database, by expanding its motif catalog and integrating it with ENCODE data to annotate candidate regulatory sites and provide tools for variant and disease analysis.