Ross Swofford

The paper introduces a data model for longitudinal multimodal biomedical cohorts, demonstrating its ability to manage heterogeneous data across multiple modalities and study visits.

This study uses untargeted sequencing to analyze population genetics and pathogen surveillance in timber rattlesnakes, finding genetic distinctness and a color variation locus linked to ALDH4A1.

This study evaluates how preanalytical factors affect liquid biopsy in canine cancer models, finding that tumor content and metrics vary by blood draw location and cancer type.

This study compares genomic features of dog and human cancers across multiple types, finding widespread shared mutational signatures and genes, suggesting dogs as valuable models for precision oncology.

The paper expands the ENCODE Registry of candidate cis-regulatory elements (cCREs) to include 2.35 million human and 927 thousand mouse cCREs, revealing novel regulatory functions and identifying KLF1 as a causal gene for red blood cell traits.

A 240-species placental mammal alignment resolves constraint to single bases, estimating at least 10.7% of the human genome is constrained, with 48.5% of constrained bases unannotated.

The paper predicts the broad host range of SARS-CoV-2 by analyzing ACE2 conservation across vertebrates and identifying high-risk species.

The paper compares genomic features of canine and human angiosarcoma, finding shared genes and pathways, suggesting dogs as a valuable model for studying this cancer.

The paper uses an OU process to model gene expression evolution across mammals and identifies expression pathways under different selection pressures.

The paper identifies OCD-associated genes by combining evolutionary and functional data with targeted sequencing in humans and animal models.