Author

Xiaotong T. He

Cancer Research UK Manchester CentreORCID 0000-0003-4017-2037Unclaimed ORCID profile · follow to get notified of new preprints

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Aldo ScarpaiD· 1 shared Alessandra PulvirentiiD· 1 shared Andrew V. Bainkin· 1 shared Antonio PeaiD· 1 shared Claudio LuchiniiD· 1 shared Colin J. McKay· 1 shared David C. Wedge· 1 shared David K. Chang· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperCancer Biology

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1 paper

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedMar 4, 2026

Clonal evolutionary analysis reveals patterns of malignant transformation in pancreatic cancer from Intraductal Papillary Mucinous IPMN Neoplasms (IPMN)

Antonio Pea, Xiaotong T. He, Rosie Upstill-Goddard…·David K. Chang

This study traces the clonal evolution of pancreatic cancer from IPMN using genomic and transcriptomic data, identifying two distinct evolutionary trajectories and their implications for PDAC progression.

2 citations

humanwhole-genome sequencing

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