Guihu Zhao

This study analyzes the intratumoral microbiome in DFSP using WGS data and finds negative correlations between microbial diversity and tumor malignancy markers like Ki67 expression.

This study uses Mendelian randomization to investigate causal relationships between smoking and 42 diseases, finding six causal links and a genetic correlation with gastroesophageal reflux disease.

The paper evaluates 24 computational methods for predicting non-coding variant function and pathogenicity across four benchmark datasets, finding varying performance across different variant types.

AsCRISPR is a web tool for designing allele-specific gRNAs to target mutant alleles or SNPs while preserving normal alleles, with evaluations of on-target efficiency and off-target potential.