Zheng Wang

LucaCell: a sequence-centric foundation model for cross-species single-cell analysis

LucaCell is a sequence-centric foundation model that improves cross-species single-cell analysis by using mRNA sequence embeddings instead of fixed gene identifiers.

Small molecule activation of the tumor suppressor kinase LKB1

This study develops small molecules that activate the tumor suppressor kinase LKB1 and shows their therapeutic benefits in cancer cell lines.

CellChem: Cellular transcriptional responses reshape molecular representation space for efficient and multi-scale drug discovery

CellChem learns cell-guided molecular representations that integrate structure and function, improving drug discovery by capturing cellular response similarities.

GENERanno: A Genomic Foundation Model for Metagenomic Annotation

Generanno is a genomic foundation model optimized for metagenomic annotation, achieving superior accuracy in coding region identification and enabling pseudogene prediction and taxonomic classification without reference databases.

An Investigation into Mechanomyography for Signal Extraction and Classification of Human Lower Limb Activity

This paper uses FMD to isolate MMG signals from ACC data and develops a TCN-Attention model for classifying lower limb activities with 98.44% accuracy.

Genetic correlation and causality between smoking and 42 neuropsychiatric and gastrointestinal diseases

This study uses Mendelian randomization to investigate causal relationships between smoking and 42 diseases, finding six causal links and a genetic correlation with gastroesophageal reflux disease.

Metatranscriptomics supports mechanism for biocathode electroautotrophy by "Candidatus Tenderia electrophaga"

The paper uses metatranscriptomics to validate and refine the proposed pathway for extracellular electron transfer coupled to carbon fixation in 'Candidatus Tenderia electrophaga' in biocathode communities.