Murali Ramachandra

This paper identifies a druggable chromatin vulnerability in suppressive neutrophils that can restore antitumor immunity through mSWI/SNF antagonists.

This paper develops a dual-reporter HTS assay to identify HIV-1 latency-modulating agents, finding 27 candidate LPAs and LRA compounds from a chemical library.

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.