Evolutionary BiologybioRxivPreprint
Theoretical origins of extreme cell differentiation irreversibility: a dynamic model of organismal size effects
Yuanxiao Gao, Xueyan Zhao, Caixia Li
The paper develops a dynamic model showing that extreme cell differentiation irreversibility evolves most robustly in intermediately sized multicellular organisms, revealing a non-monotonic relationship between organismal size and cell fate determinism.
DOI 10.1101/2025.04.20.649670