Yuanxiao Gao

The evolution of irreversible cell differentiation under cell death effect

This study investigates how cell death influences the evolution of irreversible cell differentiation in multicellular organisms, showing that linear death rate differences between cell types promote irreversible differentiation.

Theoretical origins of extreme cell differentiation irreversibility: a dynamic model of organismal size effects

The paper develops a dynamic model showing that extreme cell differentiation irreversibility evolves most robustly in intermediately sized multicellular organisms, revealing a non-monotonic relationship between organismal size and cell fate determinism.

Full-length RNA transcript sequencing traces brain isoform diversity in house mouse natural populations

The paper sequences full-length RNA transcripts from multiple mouse species to catalog isoform diversity and refine genome annotation.