Sunil R. Lakhani

The paper analyzes paired breast carcinomas to determine if recurrences are clonal or new tumors, finding 7% are non-clonal by whole exome sequencing.

This study demonstrates calcium signaling communication between breast cancer and neural cells in a brain metastasis model using single-cell imaging.

This paper integrates tumor homologous recombination deficiency status with germline BRCA1 and BRCA2 variant classification to improve pathogenicity prediction.

This study identifies hotspot KRAS mutations as enriched in early brain metastases of melanoma, associated with worse survival and clonal origin, suggesting potential for risk stratification.

This paper introduces qCNV and sCNA-seq tools to profile somatic copy number alterations in cell-free DNA without a reference panel, showing effectiveness in detecting clinically relevant mutations from plasma samples.