Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinomaprecursors
Michail Ch. Sideris, Eleni Maniati, Tanjina Kader…·Ranjit Manchanda
This study reconstructs transcriptional trajectories of Fallopian-tube epithelium to show STICs occupy diverse positions along a progression continuum and exhibit variable PARPi resistance signatures.