Roy Rabbie

Pan-cancer analysis in the real-world setting uncovers immunogenomic drivers of acquired resistance post-immunotherapy

This study identifies immunogenomic drivers of acquired resistance to immunotherapy across multiple cancer types using a large-scale clinicogenomic dataset.

Tumour gene expression signature in primary melanoma predicts long-term outcomes: A prospective multicentre study

This paper develops a gene expression signature, Cam_121, to predict long-term outcomes in primary melanoma patients, showing improved accuracy compared to clinical and existing prognostic models.

Hotspot KRAS mutations in brain metastases at the first metastatic recurrence of cutaneous melanoma

This study identifies hotspot KRAS mutations as enriched in early brain metastases of melanoma, associated with worse survival and clonal origin, suggesting potential for risk stratification.

Multi-site clonality analyses uncovers pervasive subclonal heterogeneity and branching evolution across melanoma metastases

The paper analyzes whole-genome sequencing data from melanoma metastases to show that branched evolution is common and that subclonal heterogeneity is prevalent in metastatic melanoma.