Author

Päivi H. Hartikainen

Kuopio University HospitalORCID 0000-0003-4081-9216Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Annakaisa HaapasaloiD· 3 shared Anne M. PortaankorvaiD· 3 shared Dorit B. HoffmanniD· 3 shared Eino SoljeiD· 3 shared Hannah RostalskiiD· 3 shared Nadine HuberiD· 3 shared Sami HeikkineniD· 3 shared Tomi HietaneniD· 3 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Annakaisa HaapasaloORCID

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3 papers

Recent·Most cited

NeuroscienceMolecular PsychiatryPeer-reviewedSep 26, 2025

Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage

Nadine Huber, Tomi Hietanen, Sami Heikkinen…·Annakaisa Haapasalo

This study shows that iPSC-derived neurons from FTD patients exhibit synaptic dysfunction, DNA damage, and C9-HRE-related pathologies, supporting synaptic dysfunction as a key factor in FTD.

4 citations

humanexperimental assay

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NeurosciencebioRxivPreprintAug 14, 2024

C9orf72 repeat expansion-carrying iPSC-microglia from FTD patients show increased phagocytic activity concomitantly with decreased number of autophagosomal-lysosomal vesicles

Hannah Rostalski, Tomi Hietanen, Dorit B. Hoffmann…·Annakaisa Haapasalo

This study shows that C9orf72 repeat expansion in iPSC-derived microglia from FTD patients leads to increased phagocytic activity and reduced autophagosomal-lysosomal vesicles.

2 citations

humanbulk RNA-seq

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NeurosciencebioRxivPreprintMay 28, 2024

Fibroblasts carrying intermediate C9orf72 hexanucleotide repeat expansions from iNPH patients show impaired energy metabolism but no cell pathologies

Dorit B. Hoffmann, Ville E. Korhonen, Hannah Rostalski…·Annakaisa Haapasalo

DOI 10.1101/2024.05.28.595117

humanbulk RNA-seq

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