Fiorella Schischlik

The paper infers tumor immune status and predicts immunotherapy response from blood scRNA-Seq data in HNSCC patients.

The paper predicts anti-SARS-CoV-2 targets by identifying synthetic lethal partners of host genes altered during infection, validated through CRISPR-Cas9 screens and siRNA experiments.

The paper develops CODEFACS and LIRICS to deconvolve bulk gene expression and identify clinically relevant ligand-receptor interactions in tumors, finding specific T-cell interactions linked to anti-PD1 response.

The paper uses single-cell transcriptomics data to explore optimal combination therapies for cancer by analyzing receptor targets across multiple tumor types.