Author

Sougata Guha

Istituto Nazionale di Fisica Nucleare, Sezione di NapoliORCID 0000-0003-4376-0731Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:simulation· 1

Frequent Co-Authors

Mario NicodemiiD· 2 shared Mattia ConteiD· 2 shared Sumanta KunduiD· 2 shared Alex AbrahamiD· 1 shared Andrea EspositoiD· 1 shared Andrea FontanaiD· 1 shared Andrea M. ChiarielloiD· 1 shared Ciro Di CarluccioiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Mario NicodemiORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 26, 2026

Scaling of structural variability of ecDNA polymer condensates with copy number boosts and stabilises oncogene regulatory contacts

Mattia Conte, Sumanta Kundu, Sougata Guha, Mario Nicodemi

The paper develops a polymer physics model of ecDNA condensates showing that structural variability scales with copy number, stabilizing oncogene regulatory contacts.

DOI 10.64898/2026.09.25.754334

statistical modelgene regulatory network inference

𝕏 PostBluesky

BiophysicsbioRxivPreprintMay 20, 2025

Physical principles of phase-separation action on chromatin looping associated to pathogenic gene activation

Sougata Guha, Andrea Fontana, Alex Abraham…·Andrea M. Chiariello

The paper uses polymer physics models and simulations to show how chimeric proteins cause aberrant chromatin looping, and proposes strategies to inhibit this process.

1 citation

humanChIP-seq

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BiophysicsThe Journal of Chemical PhysicsPeer-reviewedMay 19, 2025

Binder and monomer valencies determine the extent of collapse and reswelling of chromatin

Sougata Guha

This study uses simulations to show that binder valency drives chromatin collapse while monomer valency determines reswelling, with two distinct mechanisms identified.

3 citations

statistical modelsimulation

𝕏 PostBluesky