Author

Chrishan J. A. Ramachandra

Duke-NUS Medical SchoolORCID 0000-0003-4379-3795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Physiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:E. coli· 1

Frequent Co-Authors

Derek John HausenloyiD· 3 shared Gustavo E Crespo-AvilaniD· 2 shared Ying‐Hsi Lin· 2 shared Aditya Iyer· 1 shared Aishwarya Prakash· 1 shared Akshamal Mihiranga GamageiD· 1 shared Chee Jian PuaiD· 1 shared Daniel OffeniD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBioinformatics

Derek John HausenloyORCID

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Author profile →

3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintDec 15, 2025

A Population-Scale Single-Cell Atlas of the Human Heart Reveals Cellular Remodeling and Cell-Cell Communication in Aging and Cardiac Disease

Zheng Gong, Mengwei Li, Kok Siong Ang…·Jinmiao Chen

The paper constructs a large-scale heart atlas and identifies cellular changes and communication patterns in aging and disease using a new computational method.

1 citation

humanscRNA-seq

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Systems BiologybioRxivPreprintMay 15, 2025

Cardiac Adaptations in the Cave Nectar Bat Eonycteris spelaea: Insights into Metabolic Resilience and Stress Response

Fan Yu, Akshamal Mihiranga Gamage, K.P. Myu Mai Ja…·Derek John Hausenloy

This study examines cardiac adaptations in the cave nectar bat Eonycteris spelaea, revealing enhanced metabolic pathways, structural remodeling, and cellular resilience that support high energy demands and stress resistance.

DOI 10.1101/2025.05.15.653669

mousehuman

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PhysiologybioRxivPreprintJun 24, 2024

The DJ-1-derived peptide, ND-13, confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathway

Aishwarya Prakash, Gustavo E Crespo-Avilan, Sze Jie Loo…·Derek John Hausenloy

This study shows that the DJ-1-derived peptide ND-13 reduces myocardial infarct size and preserves cardiac function by inhibiting mitochondrial fission and improving mitochondrial bioenergetics through the RhoA-ROCK1-Drp1 pathway.

1 citation

mouseexperimental assay

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