Author

Daniel Offen

Tel Aviv UniversityORCID 0000-0002-1102-4521Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Ahmad M. Abu-AkeliD· 1 shared Aishwarya Prakash· 1 shared Aladin SamaraiD· 1 shared Arwa QasimiD· 1 shared Ashwani ChoudharyiD· 1 shared Assaf ZingeriD· 1 shared Aviram ShemeniD· 1 shared Ayala Gover‐Proaktor· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperNeuroscience

Ahmad M. Abu-AkelORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Extracellular Vesicles from Stem cells Rescue Cellular Phenotypes and Behavioral Deficits in SHANK3-Associated ASD Neuronal and Mouse Models

Ashwani Choudhary, Idan Rosh, Yara Hussein, Shai Netser, Aviram Shemen, Taghreed Suliman, Wote Amelo Rike, Lilach Simchi, Boris Shklyar, Ahmad M. Abu-Akel, Assaf Zinger, Daniel Offen, Shlomo Wagner, Shani Stern

This study shows that EVs from stem cells can rescue cellular and behavioral deficits in Shank3-deficient models of ASD.

Cell Death and Disease · Feb 22, 2026Peer-reviewedNeuroscience

CytoLight: A Rapid and Versatile Fluorescent-Based Labeling Method for Extracellular Vesicle Characterization and Tracking

Ido Rosen, Ella Itzhaki, Ayala Gover‐Proaktor, Saar Shapira, Shirly Partouche, Lamis Qassim, Shay Grinshpan-Langman, Arwa Qasim, Daniella Levy Erez, Feba John, Ziv Porat, Neta Ben-Chaim Moskovits, Romy R. Zemel, Tali Ben‐Zur, Pia Raanani, , Aladin Samara

CytoLight is a fluorescent labeling method for extracellular vesicles that avoids aggregation and artifacts, offering reliable quantification and tracking in vitro and in vivo.

bioRxiv · Feb 11, 2026 · PreprintCell Biology

The DJ-1-derived peptide, ND-13, confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathway

Aishwarya Prakash, Gustavo E Crespo-Avilan, Sze Jie Loo, En Ping Yap, Jasper Chua, Jianhong Ching, Zeng Yitong, Ying‐Hsi Lin, Whendy Contreras, Fan Yu, Shuo Cong, Linh Chi Dam, Chrishan J. A. Ramachandra, Siavash Beikoghli Kalkhoran, Shengjie Lu, , Derek John Hausenloy

This study shows that the DJ-1-derived peptide ND-13 reduces myocardial infarct size and preserves cardiac function by inhibiting mitochondrial fission and improving mitochondrial bioenergetics through the RhoA-ROCK1-Drp1 pathway.

bioRxiv · Jun 24, 2024 · PreprintPhysiology

Induced neural differentiation of human mesenchymal stem cells affects lipid metabolism pathways

Pnina Green, Inna Kan, Ronit Mesilati‐Stahy, Nurit Argov-Argaman, Daniel Offen

This study shows that inducing neural differentiation in human mesenchymal stem cells alters lipid metabolism pathways, specifically affecting arachidonic acid and docosahexaenoic acid metabolism.

bioRxiv · Jan 17, 2021 · PreprintNeuroscience

Prediction of synonymous corrections by the BE-FF computational tool expands the targeting scope of base editing

Roy Rabinowitz, Shiran Abadi, Shiri Almog, Daniel Offen

BE-FF identifies suitable base editors to correct single nucleotide variations, enabling synonymous corrections for 19.4% of transition mutations and 298 transversion cases.

Nucleic Acids Research · Mar 24, 2020Peer-reviewedBioinformatics