Roderick C. Slieker

The paper replicates ten novel loci associated with human plasma N-glycosylation using MALDI-MS and UHPLC-FD data and identifies potential causal genes.

The paper identifies cell type-specific lncRNAs in human kidneys and finds TARID, a podocyte-specific lncRNA, is upregulated in diabetic kidney disease and critical for actin cytoskeleton reorganization.

The paper identifies age-related increases in DNA methylation variability on the inactive X chromosome in females and males, with aVMCs accumulating in XCI regions and showing replication in purified cell types.

dsSwissKnife enables federated data analysis in R, supporting biomarker discovery across harmonized datasets from multiple observational cohorts.

The paper introduces the R-package CONQUER to analyze type 2 diabetes risk loci by integrating genomic and epigenomic data, revealing tissue-shared effects on metabolic and HLA pathways.