Author

Y P Chen

University of WashingtonORCID 0000-0003-4406-1166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Assay:whole-exome sequencing· 2

Frequent Co-Authors

Douglas M. FowleriD· 2 shared Jeremy StoneiD· 2 shared Lea M. StaritaiD· 2 shared Mariam BenazouziD· 2 shared Mark W. CraveniD· 2 shared Predrag Radivojac AiD· 2 shared Ross StewartiD· 2 shared Shantanu JainiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Douglas M. FowlerORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintMar 31, 2026

Gene- and domain-aware calibration increases the clinical utility of variant effect predictors

Y P Chen, Shawn Fayer, Shantanu Jain…·Vikas Rao Pejaver

This paper improves variant effect predictors by calibrating them gene- and domain-aware, increasing evidence assignment and accuracy for variant classification.

1 citation

humanwhole-exome sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintFeb 23, 2026

A scalable approach to resolving variants of uncertain significance

Malvika Tejura, Y P Chen, Abbye E. McEwen…·Lea M. Starita

The paper develops a scalable workflow to reclassify variants of uncertain significance using experimental and predictive evidence, resolving 75% of VUS in 40 genes.

4 citations

humanwhole-exome sequencing

𝕏 PostBluesky