Author

Xiaoru Sun

Shandong UniversityORCID 0000-0003-4435-4348Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genetic & Genomic Medicine· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Fuzhong XueiD· 2 shared Hongkai LiiD· 2 shared Lei HouiD· 2 shared Zhongshang YuaniD· 2 shared Chuandi JiniD· 1 shared Di He· 1 shared Guoqing ZhangiD· 1 shared Hansaim LimiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Fuzhong XueORCID

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4 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintDec 19, 2025

JointMR: A joint likelihood-based approach for causal effect estimation in overlapping Mendelian Randomization studies

Sijia Wu, Lei Hou, Zhongshang Yuan…·Hongkai Li

JointMR integrates GWAS summary databases to estimate causal effects, providing unbiased and reliable results with higher power and better Type I error control than traditional methods.

DOI 10.64898/2025.12.18.25342634

GWAS summary statisticsstatistical model

𝕏 PostBluesky

BioinformaticsbioRxivPreprintMar 16, 2025

High-efficiency likelihood inference of shared proteomic architectures across 50 complex human traits

Xiaoru Sun, Sizhe Yang, Qianqian Peng…·Menghan Zhang

This study introduces LEAP, a method for estimating shared proteomic architectures across traits, finding 585 significant proteomic correlations among 50 traits using UK Biobank data.

DOI 10.1101/2025.03.16.643065

humanproteomics

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BioinformaticsbioRxivPreprintDec 7, 2021

Consequence of adjustments for demographic or clinical covariates and a recommended solution in genome-wide association studies

Xiaoru Sun, Hongkai Li, Yuanyuan Yu…·Fuzhong Xue

This paper evaluates GWAS adjustment strategies and recommends adjusting for SNPs in linkage disequilibrium rather than demographic or clinical covariates.

DOI 10.1101/2021.12.07.471675

GWAS summary statisticsstatistical model

𝕏 PostBluesky

Systems BiologyPLoS Computational BiologyPeer-reviewedJun 17, 2019

Rational Discovery of Dual-Action Multi-Target Kinase Inhibitor for Precision Anti-Cancer Therapy Using Structural Systems Pharmacology

Hansaim Lim, Di He, Yue Qiu…·Lei Xie

The paper develops a multi-target screening platform to discover dual-action drugs for cancer therapy, identifying levosimendan as a potential candidate that reduces heart failure risk and inhibits cancer growth.

55 citationstop 4%

humanmachine learning (classical)

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