Author

Alan Mackay‐Sim

Griffith UniversityORCID 0000-0003-4446-5371Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:database / resource· 1

Frequent Co-Authors

Alexandre S. CristinoiD· 2 shared Anne Maria KoivistoiD· 2 shared Anthony Robert WhiteiD· 2 shared Elina PenttiläiD· 2 shared Heikki LöppöneniD· 2 shared Juha-Matti LehtolaiD· 2 shared Katja M. KannineniD· 2 shared Riikka LampineniD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alexandre S. CristinoORCID

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4 papers

Recent·Most cited

Cell BiologyNeurobiology of DiseasePeer-reviewedJun 13, 2024

Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress

Hannah C. Leeson, Julio Aguado, Cecilia Gómez‐Inclán…·Ernst Jurgen Wolvetang

This study uses patient-derived iPSCs and organoids to show mitochondrial dysfunction and oxidative stress in AT, which can be mitigated by ATM correction or antioxidants.

23 citations

humanscRNA-seq

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NeurosciencebioRxivPreprintAug 22, 2022

An Alzheimer's disease patient-derived olfactory cell model identifies gene expression changes associated with cognition

Laura M. Rantanen, Mainá Bitar, Riikka Lampinen…·Anthony Robert White

The paper uses olfactory cells from Alzheimer's patients to identify gene expression changes linked to cognitive decline.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 24, 2020

Disease specific alterations in the olfactory mucosa of patients with Alzheimer's disease

Riikka Lampinen, Mohammad Feroze Fazaludeen, Simone Avesani…·Katja M. Kanninen

This study identifies disease-specific gene expression and protein secretion patterns in olfactory mucosa cells from Alzheimer's patients, revealing potential diagnostic and mechanistic insights.

1 citation

humanbulk RNA-seq

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NeurosciencebioRxivPreprintAug 26, 2020

Adolescent-onset and adult-onset schizophrenia: reduced ribosomal protein expression via mTOR signalling in patient-derived olfactory cells

Yichen Li, Melanie Föcking, Alexandre S. Cristino…·Alan Mackay‐Sim

This study compares proteomic profiles of olfactory cells from adolescent- and adult-onset schizophrenia patients, finding similar downregulation of ribosomal proteins and mTOR pathway components.

DOI 10.1101/2020.08.26.267930

humanproteomics

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