Author

Chen Bai

Chinese University of Hong KongORCID 0000-0003-4560-3019Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:contrastive learning· 1 Approach:diffusion model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Yingchao Yan· 2 shared Arieh WarsheliD· 1 shared Huabin Du· 1 shared Peng WuiD· 1 shared Ruifeng ZhouiD· 1 shared Song WuiD· 1 shared Tzong-Yi LeeiD· 1 shared Xiangyu Li· 1 shared

Activity by Year

2024-2026 · peak 1/yr

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10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Yingchao Yan

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintAug 22, 2026

PAM-DB: Revealing Protein Activation Mechanisms for Next-Generation Rational Drug Discovery

Xiaohong Zhu, Xiangyu Li, Yaning Hou…·Chen Bai

This paper introduces PAM-DB, a structural database mapping activation trajectories of drug targets, enabling improved drug design by incorporating dynamic conformational data.

DOI 10.64898/2026.08.20.745895

protein structuredrug response / drug discovery

𝕏 PostBluesky

BioinformaticsBriefings in BioinformaticsPeer-reviewedMar 27, 2024

Guided Diffusion for molecular generation with interaction prompt

Peng Wu, Huabin Du, Yingchao Yan…·Song Wu

This paper introduces InterDiff, a diffusion model guided by atomic interactions to generate molecules with desired ligand-protein interactions, showing improved or comparable binding modes to known drugs.

15 citations

diffusion modelcontrastive learning

𝕏 PostBluesky