Alexander V. Margetts

This study identifies divergent post-transcriptional neuroimmune responses in microglia following morphine and methamphetamine exposure, revealing persistent splicing changes in morphine that may contribute to opioid use disorder pathophysiology.

This study identifies CGRP-expressing parabrachial nucleus neurons as regulators of opioid reinforcement, suggesting new therapeutic targets for OUD.

The paper identifies distinct transcriptional changes in dopamine neurons during cocaine taking and craving using a mouse model and nuclear RNA-sequencing.

This study uses CUT&Tag-Direct to analyze histone modifications in microglia across brain regions, revealing region-specific transcriptional networks and epigenetic signatures.

This study shows methamphetamine induces long-term transcriptional and morphological changes in microglia that contribute to drug-seeking behavior and may inform treatment strategies for methamphetamine use disorder.