Systems BiologyPLoS Computational BiologyPeer-reviewed
The number of active metabolic pathways is bounded by the number of cellular constraints at maximal metabolic rates
Daan H. de Groot, Coco van Boxtel, Robert Planqué…·Bas Teusink
The paper shows that maximizing microbial growth rate limits the number of active metabolic pathways to the number of enzyme expression constraints, explaining simple metabolic behaviors through evolutionary optimization.
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