Dhruba Jyoti Mech

This study proposes a biomechanical mechanism for collagen architecture in articular cartilage, showing how fluid flow from joint movements guides fiber alignment and adapts to activity and disease.

This study develops a mathematical model of ATP metabolism in chondrocytes to show that chronic hypoxia shifts metabolism to glycolysis, reducing ATP and causing ECM loss, with therapeutic success requiring metabolic and structural interventions.