Mohd Suhail Rizvi

Length scale of cellular activity determines signatures of epithelial remodeling

The paper uses an active vertex model to show that spatial velocity correlations can distinguish four modes of epithelial activity based on their spatial organization and dynamics.

SARS-CoV-2 PLpro Hijacks a Conserved Stress Signaling Network to Drive Organ-Specific Loss of Epithelial Homeostasis

This paper identifies SARS-CoV-2 PLpro as a driver of epithelial stress and tissue damage across species by activating metabolic and inflammatory pathways in Drosophila and mammalian models.

Fluid flow induced biomechanical origin of collagen architecture in articular cartilage

This study proposes a biomechanical mechanism for collagen architecture in articular cartilage, showing how fluid flow from joint movements guides fiber alignment and adapts to activity and disease.

Motility-Driven Viscoelastic Control of Tissue Morphology in Presomitic Mesoderm

This study uses a vertex-based model to show how cell motility affects tissue viscoelasticity and morphological responses to mechanical and biochemical cues in the presomitic mesoderm.

Modeling the role of ATP metabolism in articular cartilage and osteoarthritis

This study develops a mathematical model of ATP metabolism in chondrocytes to show that chronic hypoxia shifts metabolism to glycolysis, reducing ATP and causing ECM loss, with therapeutic success requiring metabolic and structural interventions.

Emergence of planar cell polarity from the interplay of local interactions and global gradients

The paper develops a minimal model to study how planar cell polarity emerges from local interactions and global gradients, showing that gradients enhance robustness and directionality.

Degenerating Drosophila Larval Epidermal Cells Drive Thorax Closure

The paper shows that degenerating larval epidermal cells generate pull forces that drive thorax closure in Drosophila by contracting and shrinking, facilitating HE migration and zipping.

Speed-detachment tradeoff and its effect on track bound transport of single motor protein

The paper demonstrates a speed-detachment tradeoff in motor proteins and shows how this relationship follows a power law, affecting processivity and transport efficiency.