Minfang Song

This study benchmarks five CNA inference tools using single-cell multi-omics data, finding Numbat performs best overall while CopyKAT excels with expression matrix input.

This study identifies five copy number signatures in prostate cancer using sigminer, revealing distinct etiologies and improved clinical outcome associations compared to single base substitution signatures.

The paper introduces ISnorm, a normalization method for single-cell RNA sequencing data using internal spike-in-like genes, which improves downstream analysis by accounting for transcriptome heterogeneity.