Li Lin

This study uses a clonal analysis approach to investigate HSC self-renewal and differentiation in native hematopoiesis, revealing patterns of clonal expansion and lineage commitment.

The paper introduces ISnorm, a normalization method for single-cell RNA sequencing data using internal spike-in-like genes, which improves downstream analysis by accounting for transcriptome heterogeneity.

The paper introduces epiConv, a method for integrating scATAC-seq datasets from multiple sources, improving batch correction and enabling co-assay alignment and biological condition integration.