Altered mechanical properties of astrocytes lacking MLC1; implications for the leukodystrophy MLC
Quinty Bisseling, Emma M. J. Passchier, Freya Kirwan, Nelda Antonovaité, Serena Camerini, Maria Stefania Brignone, Amélie Freal, Huibert D. Mansvelder, Elena Ambrosini, Marjo S. van der Knaap, Rogier Min
This study shows that Mlc1-null astrocytes are softer and have altered cytoskeleton-membrane-ECM interactions, suggesting a role for mechanobiology in MLC pathogenesis.
Glia · Dec 2, 2025Peer-reviewedNeuroscience