Huibert D. Mansvelder

This study compares age-specific pediatric EEG templates to adult templates and finds they better match individual MRI-based biomarkers in children up to 12 years old.

The paper identifies the medial prefrontal cortex as the strongest cortical input to the lateral hypothalamus, with distinct synaptic dynamics and integration patterns.

This study investigates how anterior insula cortex activity relates to alcohol and social reward choice in rats, finding that increased aIC activity correlates with decision bias towards alcohol.

This study shows that Mlc1-null astrocytes are softer and have altered cytoskeleton-membrane-ECM interactions, suggesting a role for mechanobiology in MLC pathogenesis.

The paper develops computational models to analyze E/I ratio and E+I strength in brain disorders, finding distinct patterns in epilepsy, Alzheimer's, autism, and ADHD.

This study shows human cortical neurons mature slowly into adulthood, unlike mice, and develops a model to simulate this process across species.

The paper examines EEG abnormalities in ASD and controls, finding reduced fE/I in both groups with abnormalities, suggesting inhibition-dominated networks in sensory regions.

This study investigates whether seizures exacerbate myelin vacuolization and astrocyte swelling in a mouse model of MLC, finding no significant acute worsening of these features.

This study investigates how lateral hypothalamic GABAergic neurons encode and express alcohol-related memories through behavioral experiments and optogenetic manipulation.

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

The paper shows that biophysical properties of Na+ and K+ channels in human pyramidal neurons enable fast and reliable input-output signaling.

The paper identifies structural and functional adaptations in human fast spiking neurons that enable fast inhibition despite increased cortical distances.

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

The paper maps morpho-electric and computational properties of human hippocampal CA1 pyramidal neurons and identifies three distinct cell types with unique biophysical features.

The paper compares dendritic architecture in human and mice neuronal networks, finding that human pyramidal cells have greater dendritic complexity, contributing to increased network complexity despite lower neuron density.

This study shows that astrocyte leaflet structure, regulated by Ezrin, affects memory strength by controlling glutamate diffusion and synaptic function in the hippocampus.

The paper identifies GABAergic inputs from the mesodiencephalic junction to the basilar pontine nuclei and shows they are processed separately from motor cortical inputs.

This study identifies the anterior insula cortex's role in context-induced relapse to nicotine-seeking using a rodent model and chemogenetic inhibition.

The paper links functional network integration in the default mode network to cellular properties in TLE patients, showing correlations between network centrality and memory performance.

The paper shows that criticality optimizes phase coupling and information transfer between brain networks, and that neuromodulation of synaptic strength regulates this critical dynamics.

The paper shows that expanded layers 2 and 3 in the left temporal cortex correlate with higher verbal intelligence scores and specific neuronal features.

The paper shows an age-dependent decline in GluN2B-containing NMDA receptors in human cortical synapses, potentially contributing to age-related cognitive decline.

The paper identifies ChAT-VIP interneurons in the medial prefrontal cortex that use cholinergic transmission to excite neurons and influence attention.

This study shows that Gpr158 deficiency in mice leads to impaired spatial memory and altered CA1 neuronal excitability and dendritic structure.

The paper links human intelligence to neuronal complexity and action potential speed in pyramidal neurons using brain tissue and imaging data.

The paper presents detailed biophysical models of human cortical pyramidal neurons, revealing enhanced computational capabilities through large synaptic conductances and multi-site nonlinear signaling.

This study shows that developing medial entorhinal cortex (MEC) networks in rodents are synchronously active in spatially-grouped modules, which may help establish spatially-tuned firing properties.