Hugo Dourado

The paper models growth costs of suboptimal protein allocation in microbial cells using growth balance analysis, showing how protein levels affect growth rates and fitness.

GBA Solver provides a web-based tool for constructing and solving GBA models with up to 20 reactions, integrating kinetic parameters and offering visualizations for cell metabolism and growth analysis.

This study introduces Growth Mechanics to show that metabolic oscillations in growing cells are necessary for maximizing fitness by optimizing resource allocation.

The paper develops two simplified growth balance analysis models for Synechocystis sp. PCC 6803 to predict cellular resource allocation under different environmental conditions and photodamage effects.

The paper derives a model predicting metabolite concentrations from enzyme concentrations and substrate affinities, showing high accuracy across E. coli and eukaryotes.