Author

Roland P. Kuiper

Princess Máxima CenterORCID 0000-0003-4928-3809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant effect prediction· 2 Assay:whole-exome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Claire PallesiD· 2 shared Richarda M. de VoeriD· 2 shared Tom van WezeliD· 2 shared Yael GoldbergiD· 2 shared Aleksandar J DimovskiiD· 1 shared Andishe AttarbaschiiD· 1 shared Andrea SottorivaiD· 1 shared Andreas J GruberiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Claire PallesORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicineHuman Genetics and Genomics AdvancesPeer-reviewedJul 18, 2025

Clinical syndromes linked to biallelic germline variants in MCM8 and MCM9

Noah C. Helderman, Ting Yang, Claire Palles…·Margot Julia Wyrwoll

This study identifies biallelic germline variants in MCM8 and MCM9 as linked to polyposis, gastric cancer, early-onset colorectal cancer, and hypogonadism, with MCM9 variants showing stronger associations.

3 citations

humanwhole-exome sequencing

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Cancer BiologyBloodPeer-reviewedApr 8, 2024

Mutational and transcriptional landscape of pediatric B-cell precursor lymphoblastic lymphoma

Emma Kroeze, Ingram Iaccarino, Michelle M Kleisman…·Wolfram Klapper

This study presents the first comprehensive mutational and transcriptional analysis of B-cell precursor lymphoblastic lymphoma (BCP-LBL), revealing molecular similarities to BCP-ALL but with distinct mutation patterns in epigenetic modifiers.

9 citations

humanwhole-exome sequencing

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GeneticsbioRxivPreprintApr 27, 2021

Germline loss-of-function variants in the base-excision repair gene MBD4 cause a Mendelian recessive syndrome of adenomatous colorectal polyposis and acute myeloid leukaemia

Claire Palles, Edward Chew, Judith E. Grolleman…·Richarda M. de Voer

3 citations

humanDNA methylation

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