Author

Edward Chew

Walter and Eliza Hall Institute of Medical ResearchORCID 0000-0002-1075-6616Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christoffer FlensburgiD· 2 shared Ian J. MajewskiiD· 2 shared Adil S. al Hinai· 1 shared Aleksandar J DimovskiiD· 1 shared Andrea SottorivaiD· 1 shared Andreas J GruberiD· 1 shared Andrés Dacal Rivas· 1 shared Andrew W. Roberts· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetics

Christoffer FlensburgORCID

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2 papers

Recent·Most cited

Germline loss-of-function variants in the base-excision repair gene MBD4 cause a Mendelian recessive syndrome of adenomatous colorectal polyposis and acute myeloid leukaemia

Claire Palles, Edward Chew, Judith E. Grolleman, Sara Galavotti, Christoffer Flensburg, Erik A. M. Jansen, Helen M. Curley, Laura Chegwidden, Edward H. Arbe-Barnes, Ashish R. Bajel, Kitty Sherwood, Lynn M. Martin, Huw J. W. Thomas, Demetra Georgiou, Florentia Fostira, , Richarda M. de Voer

bioRxiv · Apr 27, 2021 · PreprintGenetics

Germline loss of MBD4 predisposes to leukaemia due to a mutagenic cascade driven by 5mC

Mathijs A. Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E. Miller, Adil S. al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara Mclennan, Remco M. Hoogenboezem, François G. Kavelaars, Marnie E. Blewitt, Eric M. Bindels, Warren S. Alexander, , Ian J. Majewski

This study shows that germline MBD4 loss causes AML with high C>T mutations due to 5mC deamination, and highlights interactions with somatic DNMT3A mutations.

bioRxiv · Nov 1, 2017 · PreprintCancer Biology