Andreas J Gruber

The paper identifies a p53-FBXO44-RAD18 axis that limits mutagenesis by terminating translesion DNA synthesis after replication stress.

This study uses whole genome sequencing of endometrial cancers to identify novel subgroups, drivers, and actionable alterations, improving precision medicine approaches.

SigProfilerExtractor is a tool for de novo mutational signature extraction that outperforms existing methods and identifies four novel signatures, including one linked to tobacco smoking.

The paper develops SMEAGOL, a tool to analyze RBP binding motif enrichment in ssRNA viral genomes, finding most are enriched or depleted in human RBP motifs, suggesting selection pressure on these interactions.

The paper introduces MAPP, a method to infer RNA-binding protein impacts on pre-mRNA processing from RNA-seq data, revealing co-regulation of splicing and polyadenylation.

The paper analyzes whole-genome data from Nigerian breast cancer patients, identifying ethnic-driven somatic evolution and distinct genomic subtypes associated with African ancestry.

The paper uses bioinformatic analyses of RNA sequencing data to identify host and viral factors involved in SARS-CoV-2 pathogenesis, including differentially expressed genes and viral sequence variants linked to disease severity.

The paper develops PAQR and KAPAC to analyze PAS use and motif activities in RNA-seq data, identifying Polypyrimidine tract binding protein 1 as a regulator of PAS choice in glioblastoma.

The paper uses single-cell sequencing and mathematical modeling to estimate miRNA target parameters and uncover their in vivo hierarchy.

The paper analyzes 3′ end sequencing data to identify novel polyadenylation signals and demonstrates HNRNPC's repressive role in poly(A) site usage and 3′ end processing.