Mindaugas Margelevičius

The paper extends GTalign to support nucleic acid structures, improving alignment accuracy and reducing runtime for large-scale 3D structure comparisons.

GTcomplex improves structural alignment of macromolecular complexes by directly aligning entire complexes rather than individual chains, achieving higher accuracy and speed.

GTalign provides a fast and accurate method for protein structure alignment and search using spatial indexing, enabling efficient superposition and applications in functional and evolutionary studies.

The paper introduces a method to estimate the statistical significance of profile-profile alignments, improving alignment accuracy and sensitivity using a new algorithm for generating random profiles.