Jennifer R. Moran

The paper processes single-nuclei multi-omics data from 388 human brains to identify regulatory elements and build cell-type networks, revealing changes in aging and neuropsychiatric disorders.

The paper identifies and validates enhancer regions in primary human neural progenitor cells using capture STARR-seq, linking them to genes involved in psychiatric disease pathways.

The paper introduces STARRPeaker, a processing pipeline for STARR-seq data that improves enhancer detection by addressing sequencing biases and RNA stability effects.

The paper develops a custom ENCODE annotation for cancer genomics, highlighting TF-RBP interactions and network rewiring during oncogenesis, and validates findings using experimental assays.