Author

William Chau

University of TorontoORCID 0009-0000-2826-7987Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

Benjamín Sánchez-LengelingiD· 1 shared José Manuel Barraza-ChaveziD· 1 shared Paola DrizaiD· 1 shared Radhakrishnan MahadevaniD· 1 shared Rana Ahmed BarghoutiD· 1 shared Shengqing WuiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperBioengineering

Benjamín Sánchez-LengelingORCID

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1 paper

Recent·Most cited

BioengineeringbioRxivPreprintOct 22, 2026

Do protein representations encode variant function? Diagnosing residue-level protein attributions via embedding-space gradients

Rana Ahmed Barghout, Shengqing Wu, William Chau…·Benjamín Sánchez-Lengeling

This paper evaluates residue-level attributions in protein language models using synthetic fitness landscapes and identifies interventions that improve attribution accuracy.

DOI 10.64898/2026.10.21.760763

protein sequencestatistical model

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