BiochemistrybioRxivPreprint
Methyl substituted β-lactam framework based antibiotics and β-lactamase inhibitors: Proof of concept by computations
Vaishali Thakkur, Chandan Kumar Das, Shivani Verma…·Nisanth N. Nair
This paper presents a computational proof of concept for methyl-substituted β-lactam antibiotics that slow deacylation of the acyl-enzyme complex by 109-fold without affecting binding to β-lactamase.
DOI 10.1101/2024.01.14.575563