Chandan Kumar Das

This study identifies ToHydA, an O2-stable [FeFe]-hydrogenase from Thermosediminibacter oceani, and reveals structural features that protect the H-cluster from O2-induced degradation.

This paper presents a computational proof of concept for methyl-substituted β-lactam antibiotics that slow deacylation of the acyl-enzyme complex by 109-fold without affecting binding to β-lactamase.

The paper investigates how a designer DNA reader selectively recognizes oxidized CpG duplex marks through conformational plasticity, revealing insights into DNA-protein interactions.