Jeffrey Cifello

The paper presents an xQTL atlas of regulatory variation in the aging human brain, integrating multiple modalities and cell types across four studies, identifying more variant-molecular-trait associations by including TAD boundaries.

The paper identifies EGFR as a potential therapeutic target in Alzheimer's disease by linking a risk variant to increased EGFR expression in brain cell types through genomic analysis and CRISPRi validation.

CHARMER detects and harmonizes high-confidence chromatin interactions across tissues and Hi-C protocols, providing statistically significant, queryable data for downstream analysis.

BTS identifies causal variants and their functional contexts using GWAS data and functional genomic annotations, showing improved efficiency and biological insights.

NIAGADS provides a national data repository for Alzheimer's Disease and related dementia genetics and genomics research, hosting genome and exome sequence data from over 209,000 samples.

hipFG harmonizes and integrates diverse functional genomics data into standardized, searchable datasets for analysis workflows.

The paper introduces GenomicsDB, a public knowledgebase for Alzheimer's disease genetic datasets and annotations, enabling data sharing and discovery through harmonized GWAS summary statistics and functional annotations.