Systems BiologybioRxivPreprint
A Multiscale Protein Abundance Structured Population Kinetic Model Systematically Explores the Design Space of Constitutive and Inducible CAR-T cells
Harshana Rajakaruna, Milie Desai, Jayajit Das
This paper develops a framework called PASCAR to systematically explore CAR-T cell design space using multiscale models and optimization, showing intermediate CAR affinities reduce healthy cell lysis while maintaining tumor cell killing.
DOI 10.1101/2023.01.09.523295