Author

Harshana Rajakaruna

Nationwide Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Approach:optimal transport· 1

Frequent Co-Authors

Jayajit DasiD· 2 shared Dean A. Lee· 1 shared Indrani NayakiD· 1 shared Kun XingiD· 1 shared Kyle A. BeckwithiD· 1 shared Marcelo S. F. Pereira· 1 shared Meisam Naeimi KararoudiiD· 1 shared Milie DesaiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Jayajit DasORCID

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2 papers

Recent·Most cited

Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedJan 30, 2026

A framework integrating multiscale in-silico modeling and experimental data predicts CD33 CAR-NK cytotoxicity across target cell types

Saeed Ahmad, Kun Xing, Marcelo S. F. Pereira…·Jayajit Das

The paper develops a multiscale computational model to predict CD33 CAR-NK cytotoxicity against various target cells using experimental data and flow cytometry.

3 citationstop 4%

humanflow cytometry

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Systems BiologybioRxivPreprintJan 9, 2023

A Multiscale Protein Abundance Structured Population Kinetic Model Systematically Explores the Design Space of Constitutive and Inducible CAR-T cells

Harshana Rajakaruna, Milie Desai, Jayajit Das

This paper develops a framework called PASCAR to systematically explore CAR-T cell design space using multiscale models and optimization, showing intermediate CAR affinities reduce healthy cell lysis while maintaining tumor cell killing.

DOI 10.1101/2023.01.09.523295

humanproteomics

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