Author

Sergej Ruff

University of Veterinary Medicine Hannover, FoundationORCID 0009-0000-8264-6347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Chris LauberiD· 1 shared Klaus JungiD· 1 shared Li Chuin ChongiD· 1 shared Liubov ChuprikovaiD· 1 shared Stefan SeitziD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 6 mutual co-author links

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1 shared paperBioinformatics

Chris LauberORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJan 28, 2026

Data-Driven Virus Discovery with Virushunter and Virusgatherer

Liubov Chuprikova, Li Chuin Chong, Sergej Ruff…·Chris Lauber

This paper introduces Virushunter and Virusgatherer, tools for discovering viral genomes from sequencing data, and applies them to bat transcriptomes to identify novel virus species.

DOI 10.64898/2026.01.26.701714

mousebulk RNA-seq

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BioinformaticsBioinformatics AdvancesPeer-reviewedJan 1, 2026

scTrimClust: A Fast Approach to Robust scRNA-seq Analysis Using Trimmed Cell Clusters

Sergej Ruff, Klaus Jung

scTrimClust identifies outlier cells in scRNA-seq data by analyzing their distance to cluster borders, showing how extreme cells affect marker gene detection and analysis results.

DOI 10.1093/bioadv/vbag082

scRNA-seqstatistical model

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