Author

Melanie Foucaud Leheup

Institut ServierORCID 0009-0000-9595-5763Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Alice Griffon· 1 shared David KirklandiD· 1 shared Flavia Pasello dos SantosiD· 1 shared George E. JohnsoniD· 1 shared Richard John WeaveriD· 1 shared Stefan O. MuelleriD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperPharmacology & Toxicology

Alice Griffon

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1 paper

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintAug 27, 2026

From TD50 to Benchmark Dose in Nitrosamine Risk Assessment: Evidence from N-Nitrosotrimetazidine Carcinogenicity and TGR Mutation Data.

Melanie Foucaud Leheup, George E. Johnson, David Kirkland…·Stefan O. Mueller

This paper evaluates the carcinogenic risk of N-Nitrosotrimetazidine using in vitro and in vivo studies, deriving a benchmark dose and tumor dose to refine acceptable intake limits.

DOI 10.64898/2026.08.26.742063

ratstatistical model

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