Author

Clayton W. Moore

Texas A&M UniversityORCID 0009-0001-1033-6320Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1

Activity by Year

2026-2026 · peak 2/yr

2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintSep 17, 2026

Lacuna: Cryptic Binding Pocket Discovery via Conformational Ensemble Analysis

Clayton W. Moore

Lacuna identifies cryptic binding pockets in proteins by analyzing conformational ensembles, achieving high recovery rates on benchmark datasets.

DOI 10.64898/2026.08.14.744956

protein structurestatistical model

𝕏 PostBluesky

BioinformaticsbioRxivPreprintAug 20, 2026

Cryptic binding sites are detected but not ranked: coverage, conversion, and the limits of detector consensus

Clayton W. Moore

The paper evaluates cryptic binding site detection methods by separating coverage from ranking, showing that ranking improvements can significantly enhance recovery.

DOI 10.64898/2026.08.11.743381

protein structurestatistical model

𝕏 PostBluesky