Author

Yijia Christiana Liu

Broad InstituteORCID 0009-0001-2078-651XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 4 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:gene regulatory network inference· 3 Research Focus:GWAS / association mapping· 3 Research Focus:differential expression· 2 Research Focus:eQTL / molecular QTL mapping· 2 Assay:scRNA-seq· 2 Assay:whole-exome sequencing· 2

Frequent Co-Authors

Benjamin M. NealeiD· 4 shared Wei ZhouiD· 3 shared Ana M. Ramirez-DiaziD· 2 shared Angli XueiD· 2 shared Anna S. E. CuomoiD· 2 shared Bellis MiniD· 2 shared Calwing LiaoiD· 2 shared Carlos López‐JaramilloiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Benjamin M. NealeORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintOct 5, 2026

Rare coding variation implicates thirteen genes in bipolar disorder across 232,536 individuals from global populations

Calwing Liao, Robert Ye, Julia Sealock…·Benjamin M. Neale

DOI 10.64898/2026.09.30.26364416

humanwhole-exome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintSep 27, 2026

A founder population reveals genetic variation with major effect on serious mental illness

G. H. Gerdes, Veronica Tozzo, Susan K. Service…·Loes M. Olde Loohuis

The paper identifies a founder variant in ADAP1 associated with increased risk of schizophrenia and bipolar disorder in a Colombian genetic isolate.

DOI 10.64898/2026.09.25.26363706

humanwhole-exome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintSep 14, 2026

Scalable context-dependent single-cell eQTL mapping reveals disease-relevant regulatory variation beyond static models

Yijia Christiana Liu, Anna S. E. Cuomo, Yi Huang…·Wei Zhou

The paper introduces CASTIE, a method for context-dependent eQTL mapping in single-cell data, identifying regulatory variants missed by static models and linking them to disease traits.

1 citation

𝕏 PostBluesky

GenomicsbioRxivPreprintAug 19, 2026

Metabolic disease-relevant stimuli unmask context-dependent genetic regulation of cardiometabolic loci in human adipocytes

Yi Huang, Joaquín Pérez‐Schindler, Sanchari Datta…·Melina Claussnitzer

The paper maps context-dependent genetic regulation of cardiometabolic loci in human adipocytes using a multi-donor cell village system and single-nucleus multiome sequencing under various metabolic stress conditions.

DOI 10.64898/2026.08.12.744187

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintAug 27, 2025

Genetic regulation of cell type-specific chromatin accessibility shapes immune function and disease risk

Angli Xue, Jianan Fan, Oscar A Dong…·Joseph E. Powell

The paper maps chromatin accessibility and genetic variation in immune cells, showing how integrating cell-type-specific data improves disease risk understanding.

2 citations

humanscATAC-seq

𝕏 PostBluesky