Author

Mengyu Tu

Universitätsmedizin GöttingenORCID 0009-0001-2272-2755Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Laura UrbachiD· 2 shared Lukas KleiniD· 2 shared Shiv K. SinghiD· 2 shared Uday KishoreiD· 2 shared Volker EllenriederiD· 2 shared Alessandro MangognaiD· 1 shared Andreas TrumppiD· 1 shared Anna Blandau· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Laura UrbachORCID

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2 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedJan 6, 2025

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

Lukas Klein, Mengyu Tu, Niklas Krebs…·Shiv K. Singh

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

54 citationstop 1%

humanbulk RNA-seq

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ImmunologybioRxivPreprintOct 28, 2023

Neutrophil-derived complement factor P induces cytotoxicity in basal-like cells via caspase 3/7 activation in pancreatic cancer

Uday Kishore, Praveen Mathews Varghese, Alessandro Mangogna…·Shiv K. Singh

This study shows that neutrophil-derived complement factor P induces apoptosis in basal-like pancreatic cancer cells via caspase 3/7 activation, linking properdin expression to better prognosis.

DOI 10.1101/2023.10.28.564512

humanbulk RNA-seq

𝕏 PostBluesky