Pan Shi

The paper quantifies G0 arrest and proliferation in breast cancer using single-cell and spatial data, identifying a prolonged G0 state and its spatial organization within an immunosuppressive niche.

This study evaluates single-cell foundation models for modeling cellular plasticity, finding they can improve state resolution but are limited by domain shifts and complexity.

The paper develops methods to classify homologous recombination deficiency in breast cancer using mutational and transcriptional signatures, showing heterogeneity and single-cell microenvironment interactions.