Author

Błażej Banaszewski

Max Planck Institute of BiochemistryORCID 0009-0001-5707-5180Unclaimed ORCID profile · follow to get notified of new preprints

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Biophysics· 1

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Approach:benchmark study· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1

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Dexiong CheniD· 1 shared Karsten Michael BorgwardtiD· 1 shared L DornfeldiD· 1 shared Lukas F. MillesiD· 1 shared

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1 shared paperBiophysics

Dexiong ChenORCID

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1 paper

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BiophysicsbioRxivPreprintOct 6, 2026

✦ In-depth digest

Joint protein, mRNA and DNA sequence design and optimization with nucleotide-level Potts models

Błażej Banaszewski, L Dornfeld, Dexiong Chen…·Lukas F. Milles

A structure-conditioned nucleotide-level Potts model designs protein and coding sequences jointly, enabling tRNA adaptation and RNA motif embedding beyond synonymous codons with designability comparable to Caliby.

DOI 10.64898/2026.10.05.756407

E. coliprotein structure

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