Author

Tyler Sakamoto

Boston Children's HospitalORCID 0009-0001-5972-8288Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Tyler Sakamoto1 paper · RIKEN Center for Brain Science

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Christopher A. WalshiD· 2 shared Rebecca AnderseniD· 2 shared Abna AjeeshiD· 1 shared Caroline D. RobsoniD· 1 shared Cynthia Casson MortoniD· 1 shared David C. PageiD· 1 shared David Exposito-AlonsoiD· 1 shared Elijah L. MenaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Christopher A. WalshORCID

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2 papers

Recent·Most cited

Transcriptomic Convergence and the Female Protective Effect in Autism

Rebecca Andersen, Maya Talukdar, Tyler Sakamoto, David Exposito-Alonso, Janet H. T. Song, Xuyu Qian, Seungil Lee, Nila Murugan, Ryan Nicholas Delgado, Sijing Zhao, Gwenyth C. Eichfeld, Julia Harms, David C. Page, Christopher A. Walsh

This study shows that perturbations of ASD genes in human neural progenitor cells converge on shared transcriptomic effects, with ZFX potentially mediating the female protective effect.

bioRxiv · Jan 20, 2025 · PreprintGenetics

Rare germline disorders implicate long non-coding RNAs disrupted by chromosomal structural rearrangements

Rebecca Andersen, Ibrahim F. Alkuraya, Abna Ajeesh, Tyler Sakamoto, Elijah L. Mena, Sami Samir Amr, Hila Romi, Margaret A. Kenna, Caroline D. Robson, Ellen Wilch, Katarena Nalbandian, Raul Eduardo Piña-Aguilar, Christopher A. Walsh, Cynthia Casson Morton

The paper identifies chromosomal structural rearrangements disrupting long non-coding RNAs (lncRNAs) in individuals with rare germline disorders, highlighting potential pathogenic roles of lncRNA disruptions.

Human Genetics · Jul 1, 2024Peer-reviewedGenetic & Genomic Medicine